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Fetal blood levels tactic maternal blood levels subsequent parenteral administration. Withdrawal signs arise in infants born to Girls who get barbiturates through the entire very last trimester of pregnancy (see DRUG ABUSE AND DEPENDENCE). If phenobarbital is applied during pregnancy or In the event the patient gets to be pregnant even though using

Extravascular injection could induce neighborhood tissue destruction with subsequent necrosis; outcomes of intraarterial injection may well differ from transient agony to gangrene with the limb. Any complaint of suffering during the limb warrants halting the injection.Anticoagulants. Phenobarbital lowers the plasma levels of dicumarol and causes a

Acute or Persistent Pain. Caution really should be exercised when barbiturates are administered to clients with acute or Persistent suffering, for the reason that paradoxical enjoyment may very well be induced or vital signs may be masked.Phenobarbital can also be contraindicated in clients with marked impairment of liver perform, or respiratory si